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Henningsen JB,  Soylu-Kucharz R, Björkqvist M and Petersén Å. Heliyon. 2021 Aug 14;7(8):e07808. doi: 10.1016/j.heliyon.2021.e07808. eCollection 2021 Aug. Abstract Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. T

https://www.huntington-research.lu.se/effects-excitotoxicity-hypothalamus-transgenic-mouse-models-huntington-disease - 2025-12-03

Learn more from these short films where Åsa Petersén talks about cognitive symptoms and behavioural changes and psychiatric in Huntington's disease. Published by courtesy of Riksförbundet Huntingtons Sjukdom. All films are in Swedish. To view the Swedish subtitles, please click the button "CC" in the control bar (third from right) and choose "Svenska". Åsa Petersén about cognitive symptoms.   Åsa

https://www.huntington-research.lu.se/cognitive-symptoms-and-behavioural-changes - 2025-12-03

Gabery S, Kwa JE, Cheong RY, Baldo B, Ferrari Bardile C, Tan B, McLean C, Georgiou-Karistianis N, Poudel GR, Halliday G, Pouladi MA and Petersén Å.  Acta Neuropathologica. 142(5): 791-806 (2021) doi: 10.1007/s00401-021-02362-8. Abstract Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. The typical motor symptoms have been a

https://www.huntington-research.lu.se/early-white-matter-pathology-fornix-limbic-system-huntington-disease - 2025-12-03

Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D and Korhonen L.Human Molecular Genetics 23: 5928-5939 (2014)AbstractHuntington's disease (HD) is an autosomal inherited neurological disease caused by a CAG repeat expansion in the first exon of huntingtin gene encoding for the huntingtin protein (Htt). In HD there is an accumulation of in

https://www.huntington-research.lu.se/ubiquitin-specific-protease-14-reduces-cellular-aggregates-and-protects-against-mutant-huntingtin - 2025-12-03

Dickson E, Soylu-Kucharz R , Petersén Å and Björkqvist M. Mol Metab. 2022 Mar;57:101439. doi: 10.1016/j.molmet.2022.101439. Epub 2022 Jan 7. Abstract Objective In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progress

https://www.huntington-research.lu.se/hypothalamic-expression-huntingtin-causes-distinct-metabolic-changes-huntingtons-disease-mice - 2025-12-03

Soylu-Kucharz R, Khoshnan A and Petersén Å. iScience 2022 Jan 19;25(2):103771. doi: 10.1016/j.isci.2022.103771. eCollection 2022 Feb 18. Abstract Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an

https://www.huntington-research.lu.se/ikkb-signaling-mediates-metabolic-changes-hypothalamus-huntingtons-disease-mouse-model-0 - 2025-12-03

Dickson E, Sai Dwijesha A, Andersson N, Lundh S, Björkqvist M, Petersén Å and Soylu-Kucharz R. Frontiers in Neuroscience. 2022 Nov 3;16:1027269. doi: 10.3389/fnins.2022.1027269. PMID: 36408416; PMCID: PMC9671106. Abstract Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative diso

https://www.huntington-research.lu.se/microarray-profiling-hypothalamic-gene-expression-changes-huntingtons-disease-mouse-models - 2025-12-03

Petersén Å1 and Kirik D2.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Journal of Clinical Investigation 17:1-3 (2014)AbstractA common form of the hyperkinetic movement disor

https://www.huntington-research.lu.se/twisting-mice-move-dystonia-field-forward - 2025-12-03

Hellem MNN, Cheong RY, Tonetto S, Vinther-Jensen T, Hendel RK, Larsen IU, Nielsen TT, Hjermind LE, Vogel A, Budtz-Jørgensen E, Petersén Å and Nielsen JE. Parkinsonism and Related Disorders. 99: 23-29 (2022).  Abstract Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social c

https://www.huntington-research.lu.se/decreased-csf-oxytocin-relates-measures-social-cognitive-impairment-huntingtons-disease-patients - 2025-12-03

Bergh S, Cheong R Y, Petersén Å and Gabery S. Front. Mol. Neurosci., 14 September 2022; Sec. Molecular Signalling and Pathways; doi.org/10.3389/fnmol.2022.984317   Abstract Neurodegenerative disorders (NDDs) such as Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable popu

https://www.huntington-research.lu.se/oxytocin-huntingtons-disease-and-spectrum-amyotrophic-lateral-sclerosis-frontotemporal-dementia - 2025-12-03

Furby H, Moore S, Nordstroem A-L, Houghton R, Lambrelli D, Graham S, Svenningsson P and Petersén Å. Journal of Neurology. 270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. Abstract Background: Huntington's disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. Objective:

https://www.huntington-research.lu.se/comorbidities-and-clinical-outcomes-adult-and-juvenile-onset-huntingtons-disease-study-linked - 2025-12-03

   We are located in the Biomedical Center (BMC) in Lund in the south of Sweden. Our visiting address is Sölvegatan 17, building A11.How to get to Lund  From Copenhagen airport: Copenhagen airport Kastrup (CPH) is Denmark's international airport, and is much closer to Lund than any other international airports.Here you have direct flights from & to Asia, America and most of the European countries.

https://www.neurobiology.lu.se/visit-us - 2025-12-03

Annotaded publication list: Annotated publ list Nov 2023.pdf Most cited papers: Most cited papers 2024.pdf Publications 2010-2024To go directly to a specific year, please click on the year here: 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 20102024Alessandro Fiorenzano, Petter Storm, Edoardo Sozzi, Andreas Bruzelius, Sara Corsi, Janko Kajtez, Janitha Mudannayake, Jenny N

https://www.neurobiology.lu.se/publications - 2025-12-03

Below please find the PhD theses that have been presented at the Neurobiology Unit since 1971. To go directly to a specific year please click on the year here: 2012, 2009, 2008, 2007, 2005, 2004, 2003, 2002, 2001, 1999, 1997, 1996, 1995, 1994, 1993, 1991, 1990, 1988, 1987, 1984, 1981, 1980, 1979, 1975, 1974, 1973, 1971   2012   Shane Grealish: Cell Replacement Therapy for Parkinson's Disease: The

https://www.neurobiology.lu.se/theses - 2025-12-03

My major research achievements have been in the field of cell transplantation and brain repair. I started this line of research in the mid 1970ies, based on the idea that immature neurons can be used to replace lost neurons, restore brain circuitry, and promote functional recovery in animal models of neurodegenerative diseases. During this period, 1975-1985, my group pioneered this approach using

https://www.neurobiology.lu.se/research - 2025-12-03

   Anders Björklund, Senior ProfessorDevelopment of restorative and neuroprotective treatment strategies for Parkinson's diseaseMy research aims at developing new restorative and neuroprotective treatments for neurodegenerative diseases using cell transplantation and direct in vivo gene delivery. In collaboration with other members of the Parmar group, I'm involved in the development of stem cell

https://www.neurobiology.lu.se/about-us - 2025-12-03

The course is offered by the Department of Political Science at Lund University (Sweden) and sponsored by the ClimBEco graduate school of Lund and Gothenburg Universities. Key infoTitle: Global Environmental Governance Today – Actors, Institutions, ComplexityHosting Institution: Department of Political Science at Lund University (Sweden); sponsored by the ClimBEco graduate school of Lund and Gothe

https://www.svet.lu.se/en/research/doctoral-studies/postgraduate-courses-and-dissertation/phd-course-global-environmental-governance-today-actors-institutions-complexity - 2025-12-03

Master course. 15 credits. Political Science. Autumn term. STVN19 – New and Old Nationalism (15 credits) Nationalism has a central place in world politics, which makes it important to understand its causes and consequences. The course includes an overview of different theories of nationalism and compares previous and established ideas with contemporary contributions to the discussion.  The course

https://www.svet.lu.se/en/education/programmes-and-courses/freestanding-courses/new-and-old-nationalism - 2025-12-03

SAWEM, Master of Science Programme in Welfare Policies and Management, 120 credits. Second cycle degree programme requiring previous university study. The programme is centred on key issues in the development, policy-making, management and reform of welfare states/regimes. It is based on a comparative approach and highlights differences and similarities across countries, administrative levels and

https://www.svet.lu.se/en/education/programmes-and-courses/master-programme-welfare-policies-and-management - 2025-12-03

Master of Science Programme in European Affairs, 120 credits (SAMEA). Second cycle degree programme requiring previous university study. The general aim of the Master of Science Programme in European Affairs is to provide the student with a broad, but advanced understanding of political aspects of European Affairs. The programme conveys a number of theoretical perspectives on and approaches to the

https://www.svet.lu.se/en/education/programmes-and-courses/master-programme-european-affairs - 2025-12-03